Review-ready finding
PAXIP1 — structured candidate finding
Claim
PAXIP1 passed all registered source-QC gates in Rest, 8 h stimulation, and 48 h stimulation and ranked #10 by its weakest condition priority score. It is a reproducible source-QC candidate for independent follow-up, not an experimentally validated target.
Supporting evidence
- Rest: rank #4, priority score 0.910, minimum donor concordance 0.764, and guide concordance 0.900.
- 8 h stimulation: rank #27, priority score 0.833, minimum donor concordance 0.673, and guide concordance 0.802.
- 48 h stimulation: rank #35, priority score 0.822, minimum donor concordance 0.599, and guide concordance 0.782.
- Cross-condition maximin summary: rank #10, minimum score 0.822, with 48 h stimulation as the lowest-scoring condition.
Limitations
- The priority score is a relative triage heuristic, not a probability, p-value, or effect size.
- Downstream discovery count is power-sensitive, and donor/guide concordance values were reported by the source authors.
- Condition rank differences are descriptive because this workflow did not fit a perturbation-by-condition interaction model.
Evidence gap
No matching measurement appears in the selected author-provided IL-10/IL-21 follow-up table. Independent replication, orthogonal perturbation, formal endpoint testing, mechanism, safety, and therapeutic utility remain unestablished.
Recommended next experiment
Run an independent multi-donor CRISPRi replication for PAXIP1 with a prespecified functional endpoint in Rest, 8 h, and 48 h conditions; fit a formal perturbation-by-condition interaction before making a condition-specific claim, then confirm with an orthogonal perturbation.