Review-ready finding
CREBBP — structured candidate finding
Claim
CREBBP passed all registered source-QC gates in Rest, 8 h stimulation, and 48 h stimulation and ranked #31 by its weakest condition priority score. It is a reproducible source-QC candidate for independent follow-up, not an experimentally validated target.
Supporting evidence
- 48 h stimulation: rank #8, priority score 0.903, minimum donor concordance 0.663, and guide concordance 0.841.
- 8 h stimulation: rank #18, priority score 0.850, minimum donor concordance 0.606, and guide concordance 0.797.
- Rest: rank #68, priority score 0.726, minimum donor concordance 0.452, and guide concordance 0.759.
- Cross-condition maximin summary: rank #31, minimum score 0.726, with Rest as the lowest-scoring condition.
Limitations
- The priority score is a relative triage heuristic, not a probability, p-value, or effect size.
- Downstream discovery count is power-sensitive, and donor/guide concordance values were reported by the source authors.
- Condition rank differences are descriptive because this workflow did not fit a perturbation-by-condition interaction model.
Evidence gap
No matching measurement appears in the selected author-provided IL-10/IL-21 follow-up table. Independent replication, orthogonal perturbation, formal endpoint testing, mechanism, safety, and therapeutic utility remain unestablished.
Recommended next experiment
Run an independent multi-donor CRISPRi replication for CREBBP with a prespecified functional endpoint in Rest, 8 h, and 48 h conditions; fit a formal perturbation-by-condition interaction before making a condition-specific claim, then confirm with an orthogonal perturbation.