Review-ready finding
ARHGAP30 — structured candidate finding
Claim
ARHGAP30 passed all registered source-QC gates in 48 h stimulation. It is a condition-specific source-QC candidate for independent follow-up, not an experimentally validated target.
Supporting evidence
- 48 h stimulation: rank #5, priority score 0.910, minimum donor concordance 0.646, and guide concordance 0.913.
Limitations
- The priority score is a relative triage heuristic, not a probability, p-value, or effect size.
- Downstream discovery count is power-sensitive, and donor/guide concordance values were reported by the source authors.
- Condition rank differences are descriptive because this workflow did not fit a perturbation-by-condition interaction model.
Evidence gap
No matching measurement appears in the selected author-provided IL-10/IL-21 follow-up table. Independent replication, orthogonal perturbation, formal endpoint testing, mechanism, safety, and therapeutic utility remain unestablished.
Recommended next experiment
Run an independent multi-donor CRISPRi replication for ARHGAP30 in the eligible condition set with a prespecified functional endpoint, then confirm the result with an orthogonal perturbation and targeted mechanism assay.